Publicaciones

@article{FERNANDEZTOME2017176,

title = {Effect of the long-term intake of a casein hydrolysate on mucin secretion and gene expression in the rat intestine},

author = {Samuel Fernández-Tomé and Daniel Martínez-Maqueda and María Tabernero and Carlota Largo and Isidra Recio and Beatriz Miralles},

url = {https://www.sciencedirect.com/science/article/pii/S1756464617301536},

doi = {https://doi.org/10.1016/j.jff.2017.03.036},

issn = {1756-4646},

year  = {2017},

date = {2017-01-01},

urldate = {2017-01-01},

journal = {Journal of Functional Foods},

volume = {33},

pages = {176-180},

abstract = {The aim of the present study was to investigate the in vivo effect on rat intestinal mucus production of a casein hydrolysate that had been previously shown a mucin stimulatory effect in human goblet cells (HT29-MTX). A significant rise of O-linked glycoproteins in faeces after 2 and 8weeks of the casein hydrolysate intake was observed. In agreement with this increased secretion, the relative expression for the genes that encode the secreted MUC2 and the membrane-bound MUC3 was significantly increased in ileum and colon. Mucus material in the small intestine lumen of rats fed the casein hydrolysate was higher than that found in control rats, however the change did not reach statistical difference. This study confirms in vivo the potential effect on mucus gastrointestinal protection of this casein hydrolysate.},

keywords = {casein hydrolysate, Faecal mucin, Gene expression, O-linked glycoprotein, Rat intestine},

pubstate = {published},

tppubtype = {article}

}