Publicaciones

@article{Carrillo2018-ku,

title = {Antiulcerative Activity of Milk Proteins Hydrolysates},

author = {Wilman Carrillo and Karin Maia Monteiro and Daniel Mart'inez-Maqueda and Mercedes Ramos and Isidra Recio and Jo ao Ernesto de Carvalho},

url = {https://www.liebertpub.com/doi/10.1089/jmf.2017.0087},

doi = {https://doi.org/10.1089/jmf.2017.0087},

year  = {2018},

date = {2018-04-01},

urldate = {2018-04-01},

journal = {Journal of Medicinal Food},

volume = {21},

number = {4},

pages = {408--415},

publisher = {Mary Ann Liebert, Inc., publishers},

abstract = {Abstract Several studies have shown the protective effect of 

 dairy products, especially $alpha$-lactalbumin and derived 

 hydrolysates, against induced gastric ulcerative lesions. The 

 mucus strengthening represents an important mechanism in the 

 defense of gastrointestinal mucosa. Previously, a hydrolysate 

 from casein (CNH) and a hydrolysate from whey protein 

 concentrate rich in ?-lactoglobulin (WPH) demonstrated a 

 stimulatory activity on mucus production in intestinal goblet 

 cells. The aim of this work was to evaluate the possible 

 antiulcerative activity of these two hydrolysates in an 

 ethanol-induced ulcer model in rats. All tested samples 

 significantly reduced the ulcerative lesions index (ULI), 

 compared with the saline solution, using doses of 300 and 

 1000?mg kg?1 body weight with decreases up to 66.3% ULI. A 

 dose?response relationship was found for both hydrolysates. The 

 involvement of endogenous sulfhydryl (SH) groups and 

 prostaglandins (PGs) in the antiulcerative activity was 

 evaluated using their blockage. The antiulcerative activity of 

 WPH showed a drastic decrease in presence of N-ethylmaleimide 

 (from 41.4% to 9.2% ULI). However, the CNH antiulcerative 

 properties were not significantly affected. The cytoprotective 

 effect of WPH appears to depend on a PG-mediated mechanism. In 

 conclusion, CNH and WPH demonstrated in vivo antiulcerative 

 properties and represent a promising alternative as protectors 

 of the gastric mucosa.},

keywords = {antiulcerative activity, casein hydrolysate, peptides, rat model, whey protein hydrolysate},

pubstate = {published},

tppubtype = {article}

}