Publicaciones

@article{pmid31402656,

title = {Implication of Opioid Receptors in the Antihypertensive Effect of a Bovine Casein Hydrolysate and α-Casein-Derived Peptides},

author = {Laura Sánchez-Rivera and Pedro Ferreira Santos and M Angeles Sevilla and M José Montero and Isidra Recio and Beatriz Miralles},

url = {https://pubs.acs.org/doi/10.1021/acs.jafc.9b03872},

doi = {10.1021/acs.jafc.9b03872},

issn = {1520-5118},

year  = {2020},

date = {2020-02-01},

urldate = {2020-02-01},

journal = {J Agric Food Chem},

volume = {68},

number = {7},

pages = {1877--1883},

abstract = {The antihypertensive activity of two α-casein-derived peptides and casein hydrolysate containing these sequences was evaluated in the presence of naloxone. The activity was abolished by this opioid antagonist at 2, 4, and 6 h post-administration. Similarly, the antihypertensive effect of the α-casein peptides RYLGY (-23.8 ± 2.5 mmHg) and AYFYPEL (-21.1 ± 3.2 mmHg) at 5 mg/kg of body weight was antagonized by the co-administration of naloxone. Because peptide AYFYPEL had recently shown opioid activity, a molecular dynamic simulation of this peptide with human μ-opioid receptor was performed to demonstrate its favorable structure and interaction energy, despite the presence of Ala at the N terminus. Altogether, these results revealed that the  effect on systolic blood pressure of the studied α-casein peptides is mediated by interaction with opioid receptors and the antihypertensive activity of casein hydrolysate can be very likely ascribed to them with the possible contribution of other mechanisms.},

keywords = {antihypertensive peptide, casein hydrolysate, naloxone, opioid receptor, spontaneously hypertensive rat},

pubstate = {published},

tppubtype = {article}

}