Publicaciones

@article{FERREIRASANTOS2017168,

title = {Effects of milk casein hydrolyzate supplemented with phytosterols on hypertension and lipid profile in hypercholesterolemic hypertensive rats},

author = {Pedro Ferreira-Santos and Rosalía Carrón and Isidra Recio and M. Ángeles Sevilla and M José Montero},

url = {https://www.sciencedirect.com/science/article/pii/S1756464616303735},

doi = {https://doi.org/10.1016/j.jff.2016.11.020},

issn = {1756-4646},

year  = {2017},

date = {2017-01-01},

urldate = {2017-01-01},

journal = {Journal of Functional Foods},

volume = {28},

pages = {168-176},

abstract = {This study investigates the beneficial effect of a milk casein hydrolyzate supplemented with phytosterols in hypercholesterolemic hypertensive rats. Spontaneously hypertensive rats were fed for 8weeks with standard diet, or high cholesterol diet alone and supplemented with casein hydrolyzate or casein hydrolyzate plus phytosterols. Blood pressure was measured by tail-cuff method, vascular reactivity was performed on isolated aorta and biochemical parameters were evaluated in plasma. The hypercholesterolemic diet caused elevation of total cholesterol, low-density lipoprotein cholesterol, atherogenic index, lipid peroxidation, liver size and hepatic steatosis accompanied with a severe reduction of high-density lipoprotein cholesterol. The treatment with the casein hydrolyzate reduced blood pressure, cardiac hypertrophy and oxidative stress, and improved the endothelial function. The incorporation of phytosterols prevented the changes caused by the hypercholesterolemic diet and increased the antioxidant effect of casein hydrolyzate. In conclusion, treatment with milk casein hydrolyzate supplemented with phytosterols provides benefits when coexisting hypertension and hypercholesterolemia.},

keywords = {Casein hydrolyzate, Hypercholesterolemia, Hypertension, Phytosterols, SHR},

pubstate = {published},

tppubtype = {article}

}

@article{SANCHEZRIVERA2016348,

title = {Peptide fragments from β-casein f(134–138), HLPLP, generated by the action of rat blood plasma peptidases show potent antihypertensive activity},

author = {Laura Sánchez-Rivera and Pedro Ferreira Santos and Beatriz Miralles and Rosalía Carrón and M José Montero and Isidra Recio},

url = {https://www.sciencedirect.com/science/article/pii/S0963996915302775},

doi = {https://doi.org/10.1016/j.foodres.2015.12.007},

issn = {0963-9969},

year  = {2016},

date = {2016-01-01},

urldate = {2016-01-01},

journal = {Food Research International},

volume = {88},

pages = {348-353},

abstract = {The intact absorption of a β-casein peptide, HLPLP, into rat blood circulation after oral administration was recently demonstrated. In addition to the parent peptide, several derived fragments were detected in rat plasma. The aim of the present work is to elucidate whether these fragments retain antihypertensive activity and if their activity is mediated by angiotensin-converting-enzyme inhibition. The penta-peptide was incubated in rat plasma in order to identify and quantify the fragments generated by the action of plasmatic peptidases on HLPLP, using tandem mass spectrometry. Peptides HLPL, LPLP and HLP were generated within seconds of incubation. The parent peptide, HLPLP, and all possible derived peptides showed potent antihypertensive activity in spontaneously hypertensive rats and caused inhibition of vascular contraction elicited by angiotensin-I. It can be concluded that the antihypertensive effect of HLPLP can be produced by the concomitant action of the parent peptide and several novel derived fragments.},

note = {The 4th International Conference on Food Digestion},

keywords = {antihypertensive peptide, In vivo active form, Plasma peptidases, SHR, Tandem mass spectrometry},

pubstate = {published},

tppubtype = {article}

}